Feature Extraction of Format of Corporate Social Responsibility Reports

As an important bridge that transmits signals to the market, the corporate social responsibility report has been an important theme among stakeholders in evaluating organizational efficiency and performance. Its quality will affect the decision-making and judgment of investors, thereby affecting the response of the capital market. In recent years, social responsibility reports have shown a trend of rich pictures and diverse text designs. On the one hand, social responsibility reports composed of black and white text can hardly meet the information needs of different readers. On the other hand, reports with rich pictures and various text designs can give information users a better reading experience. However, due to the lack of uniform standards on the format of social responsibility reports, there is still a lot of space for the research on the format of social responsibility reports. This thesis explores how to effectively extract the features of social responsibility reports, so as to further explore the feature dimension, set feature indicators and analyse feature data. Firstly, existing studies have proved that the format of the social responsibility report has an impact on the stakeholder's impression management, and the way of impression management is mostly based on the design of picture arrangement, text arrangement and page structure. Secondly, the guidelines of the Shanghai Stock Exchange (the guidelines on social responsibility reports issued by the Shanghai Stock Exchange), the GRI (Global Reporting Initiative) standards take the format as an important criterion for evaluating the quality of social responsibility reports. Based on this, interviews were conducted with five researchers in the field of social responsibility. Then, a social responsibility report was taken as an example to conceptualize the feature annotation to get the two-dimensional data. Since CSR has different year data, different page data and different feature data, therefore, this thesis used Seaborn graph software to describe the three-dimension feature data. Finally, this thesis takes a report of Vanke as an example to compare the social responsibility reports of Vanke in different years, and the comparison of the layout format of the real estate industry by Vanke and the financial industry by PingAn Bank

Characteristics and sources of tissue-resident memory T cells in psoriasis relapse

Tissue-resident memory T cells (Trm) are a sub-population of memory T cells that reside in skin tissue. Recent studies have revealed potential role of Trm in the reoccurrence of psoriasis, as these cells tend to be profusely infiltrated in the lesions observed during psoriasis relapse. Trm can be classified into CD8+ Trm cells that are distributed mainly in the epidermis and CD4+ Trm cells in the dermis. CD8+ Trm is derived from circulating memory T cells and CD49a−CD8+ Trm takes a crucial role in psoriasis relapse. In contrast, CD4+ Trm may originate from exTh17 cells and exTreg cells emerging from the inflammatory process. Since IL-23 can activate Trm, neutralizing antibodies against IL-23 are suggested to be more effective in clinical treatment. This review will focus on Trm cells in psoriasis relapsed lesions to reveal their mechanisms in the pathogenesis, relapse and transformation of psoriasis

Table1_Studies on the molecular level changes and potential resistance mechanism of Coreius guichenoti under temperature stimulation.DOCX

In this study, we used transcriptome and proteome technology to analyze molecular level changes in tissues of Coreius guichenoti cultured at high temperature (HT) and low temperature (LT). We also screened for specific anti-stress genes and proteins and evaluated the relationships between them. We identified 201,803 unigenes and 10,623 proteins. Compared with the normal temperature (NT), 408 genes and 1,204 proteins were up- or down-regulated in brain tissues, respectively, at HT, and the numbers were 8 and 149 at LT. In gill tissues, the numbers were 101 and 1,745 at HT and 27 and 511 at LT. In gill tissues at both temperatures, the degree of down-regulation (average, HT 204.67-fold, LT 443.13-fold) was much greater than that of up-regulation (average, HT 28.69-fold, LT 17.68-fold). The protein expression in brain (average, up 52.67-fold, down 13.54-fold) and gill (average, up 73.02-fold, down 12.92-fold) tissues increased more at HT than at LT. The protein expression in brain (up 3.77-fold, down 4.79-fold) tissues decreased more at LT than at HT, whereas the protein expression in gill (up 8.64-fold, down 4.35-fold) tissues was up-regulated more at LT than at HT. At HT, brain tissues were mainly enriched in pathways related to metabolism and DNA repair; at LT, they were mainly enriched in cancer-related pathways. At both temperatures, gill tissues were mainly enriched in pathways related to cell proliferation, apoptosis, immunity, and inflammation. Additionally, Kyoto Encyclopedia of Genes and Genomes pathway analysis showed more differentially expressed proteins in gill tissues than in brain tissues at HT and LT, and temperature stimulation led to the strengthening of metabolic pathways in both tissues. Of the 96 genes we identified as potentially being highly related to temperature stress (59 from transcriptome and 38 from proteome data), we detected heat shock protein 70 in both the transcriptome and proteome. Our results improved our understanding of the differential relationship between gene expression and protein expression in C. guichenoti. Identifying important temperature stress genes will help lay a foundation for cultivating C. guichenoti, and even other fish species, that are resistant to HT or LT.</p

In Vivo Biosynthesized Zinc and Iron Oxide Nanoclusters for High Spatiotemporal Dual-Modality Bioimaging of Alzheimer’s Disease

Alzheimer’s disease is still incurable and neurodegenerative, and there is a lack of detection methods with high sensitivity and specificity. In this study, by taking different month old Alzheimer’s mice as models, we have explored the possibility of the target bioimaging of diseased sites through the initial injection of zinc gluconate solution into Alzheimer’s model mice post-tail vein and then the combination of another injection of ferrous chloride (FeCl₂) solution into the same Alzheimer’s model mice post-stomach. Our observations indicate that both zinc gluconate solution and FeCl₂ solution could cross the blood–brain barrier (BBB) to biosynthesize the fluorescent zinc oxide nanoclusters and magnetic iron oxide nanoclusters, respectively, in the lesion areas of the AD model mice, thus enabling high spatiotemporal dual-modality bioimaging (i.e., including fluorescence bioimaging (FL) and magnetic resonance imaging (MRI)) of Alzheimer’s disease for the first time. The result presents a novel promising strategy for the rapid and early diagnosis of Alzheimer’s disease